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KMID : 1144320120440050395
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감염과 화학요법
2012 Volume.44 No. 5 p.395 ~ p.398
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Disseminated Invasive Aspergillosis with Multiple Brain Abscess after Allogeneic Hematopoietic Stem Cell Transplantation Treated Successfully with Voriconazole and Neurosurgical Intervention
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Im Jae-Hyoung
Park In-Suh
Kim Eun-Young
Lee Jin-Soo
Lim Joo-Han
Lee Moon-Hee
Kim Chul-Soo
Lee Hyeon-Jeong
Yi Hyeon-Gyu
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Abstract
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Invasive aspergillosis is a serious infectious complication, which can occur after hematopoietic stem cell transplantation (HSCT). In particular, despite antifungal treatment, invasive aspergillosis involving the central nervous system (CNS) shows very high mortality. In principle, a neurosurgical procedure with an antifungal agent is recommended for treatment of CNS invasive aspergillosis. We encountered a patient suffering from disseminated invasive aspergillosis involving the lung, brain, and soft tissues after allogeneic HSCT for treatment of relapsed acute myeloid leukemia who was cured with voriconazole and stereotactic drainage of the brain abscess.
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KEYWORD
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Invasive aspergillosis, Central nervous system, Hematopoietic stem cell transplantation, Neurosurgical procedure, Voriconazole
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